High-Dose Oral Fluconazole Therapy Effective for Cutaneous Leishmaniasis Due to Leishmania (Vianna) braziliensis | Zendy

Anastácio Q. Sousa | Zendy; M. S. Frutuoso | Zendy; E. A. Moraes | Zendy; Richard D. Pearson | Zendy; Margarida Maria Lima Pompeu | Zendy

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High-Dose Oral Fluconazole Therapy Effective for Cutaneous Leishmaniasis Due to Leishmania (Vianna) braziliensis

Author(s) -

Anastácio Q. Sousa,

M. S. Frutuoso,

E. A. Moraes,

Richard D. Pearson,

Margarida Maria Lima Pompeu

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir496

Subject(s) - leishmania braziliensis , fluconazole , medicine , leishmania , cutaneous leishmaniasis , dermatology , leishmaniasis , cure rate , antifungal , pharmacology , immunology , parasite hosting , world wide web , computer science

We report for the first time the successful use of fluconazole to treat cutaneous leishmaniasis due to Leishmania braziliensis. We used escalating doses from 5 to 8 mg/kg per day. At a dose of 5 mg/kg per day, 75% patients were cured, and at 8 mg/kg per day, the cure rate was 100%. Fluconazole was well tolerated.

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