Early Treatment With Fluconazole May Abrogate the Development of IgG Antibodies in Coccidioidomycosis | Zendy

George R. Thompson | Zendy; Jennine M. Lunetta | Zendy; S. M. Johnson | Zendy; Sandra L. Taylor | Zendy; Declan Bays | Zendy; Stuart H. Cohen | Zendy; D. Pappagianis | Zendy

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Early Treatment With Fluconazole May Abrogate the Development of IgG Antibodies in Coccidioidomycosis

Author(s) -

George R. Thompson,

Jennine M. Lunetta,

S. M. Johnson,

Sandra L. Taylor,

Declan Bays,

Stuart H. Cohen,

D. Pappagianis

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir466

Subject(s) - coccidioides , medicine , coccidioides immitis , fluconazole , antibody , immunology , antigen , immunoglobulin g , serology , mycosis , immunoglobulin m , antifungal , dermatology

We have observed a number of patients who fail to develop coccidioidal complement fixing (CF) antibody (immunoglobulin [IgG]) after the initiation of early antifungal therapy. Although this is the first description of this phenomenon in mycology, a precedent for the abrogation of the immune response has been observed in other conditions, including primary syphilis and primary Lyme disease.

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