Cumulative Antibiotic Exposures Over Time and the Risk of Clostridium difficile Infection | Zendy

Vanessa Stevens | Zendy; Ghinwa Dumyati | Zendy; Lynn Fine | Zendy; Susan G. Fisher | Zendy; Edwin van Wijngaarden | Zendy

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Cumulative Antibiotic Exposures Over Time and the Risk of Clostridium difficile Infection

Author(s) -

Vanessa Stevens,

Ghinwa Dumyati,

Lynn Fine,

Susan G. Fisher,

Edwin van Wijngaarden

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir301

Subject(s) - medicine , clostridium difficile , antibiotics , metronidazole , hazard ratio , diarrhea , confidence interval , retrospective cohort study , antimicrobial stewardship , cohort study , antibiotic resistance , microbiology and biotechnology , biology

Clostridium difficile infection (CDI) is a major cause of hospital-acquired diarrhea and is most commonly associated with changes in normal intestinal flora caused by administration of antibiotics. Few studies have examined the risk of CDI associated with total dose, duration, or number of antibiotics while taking into account the complex changes in exposures over time.

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