Opportunistic Infection-Associated Immune Reconstitution Syndrome in Transplant Recipients | Zendy

HsinYun Sun | Zendy; N. Singh | Zendy

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Opportunistic Infection-Associated Immune Reconstitution Syndrome in Transplant Recipients

Author(s) -

HsinYun Sun,

N. Singh

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir276

Subject(s) - immunosuppression , medicine , immunology , immune system , cytomegalovirus , immune reconstitution inflammatory syndrome , opportunistic infection , pathogen , pathogenesis , virus , viral disease , herpesviridae , viral load , antiretroviral therapy

Reversal of pathogen-induced immunosuppression upon employment of effective antimicrobial therapy and withdrawal of iatrogenic immunosuppression has the potential to shift the host immune repertoire towards pathologic inflammatory responses conducive to immune reconstitution syndrome (IRS). Posttransplant IRS has been observed with fungi, M. tuberculosis, cytomegalovirus, and polyoma virus nephropathy. This review discusses the existing state of knowledge regarding IRS and the immune mechanisms that underlie its pathogenesis, with significant implications for developing reliable diagnostic biomarkers and optimal management strategies for post-transplant opportunistic infection-associated IRS.

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