Neurosurgical Gram-Negative Bacillary Ventriculitis and Meningitis: A Retrospective Study Evaluating the Efficacy of Intraventricular Gentamicin Therapy in 31 Consecutive Cases | Zendy

Thomas Tängdén | Zendy; Per Enblad | Zendy; Måns Ullberg | Zendy; Jan Sjölin | Zendy

Open Access

Neurosurgical Gram-Negative Bacillary Ventriculitis and Meningitis: A Retrospective Study Evaluating the Efficacy of Intraventricular Gentamicin Therapy in 31 Consecutive Cases

Author(s) -

Thomas Tängdén,

Per Enblad,

Måns Ullberg,

Jan Sjölin

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir197

Subject(s) - ventriculitis , medicine , meropenem , gentamicin , meningitis , external ventricular drain , surgery , antibiotics , imipenem , retrospective cohort study , anesthesia , hydrocephalus , microbiology and biotechnology , antibiotic resistance , biology

Gram-negative bacillary (GNB) ventriculitis and meningitis are rare but serious complications after neurosurgery. Prospective studies on antibiotic treatment for these infections are lacking, and retrospective reports are sparse. At our hospital in Uppsala, Sweden, meropenem has been recommended as empirical therapy since 1996, with the addition of intraventricular gentamicin in cases that do not respond satisfactorily to treatment. In this study, we retrospectively compare the efficacy of combination treatment with intraventricular gentamicin to that of systemic antibiotics alone. In addition, we report our experience of meropenem for the treatment of GNB ventriculomeningitis.

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