Adult Survivors of Invasive Pneumococcal Disease Exhibit Defective B Cell Function | Zendy

Thomas C. Darton | Zendy; James B. Wing | Zendy; Andrew Lees | Zendy; Andrew W. Heath | Zendy; Robert C. Read | Zendy

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Adult Survivors of Invasive Pneumococcal Disease Exhibit Defective B Cell Function

Author(s) -

Thomas C. Darton,

James B. Wing,

Andrew Lees,

Andrew W. Heath,

Robert C. Read

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir126

Subject(s) - medicine , pneumococcal disease , streptococcus pneumoniae , disease , pneumococcal infections , immunology , microbiology and biotechnology , antibiotics , biology

Adults who have recovered from an episode of invasive pneumococcal disease demonstrate defective B cell activation in response to αδ-dex, a polyclonal polysaccharide mimic, compared with matched control subjects. The defect is not overcome by CD4(+) T cell assistance and may explain the relatively poor response to pneumococcal vaccination in survivors of invasive pneumococcal disease.

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