Clinical Application and Limitations of Interferon- Release Assays for the Diagnosis of Latent Tuberculosis Infection | Zendy

Víctor Gallego Herrera | Zendy; S Perry | Zendy; Julie Parsonnet | Zendy; Niaz Banaei | Zendy

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Clinical Application and Limitations of Interferon- Release Assays for the Diagnosis of Latent Tuberculosis Infection

Author(s) -

Víctor Gallego Herrera,

S Perry,

Julie Parsonnet,

Niaz Banaei

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir068

Subject(s) - medicine , tuberculin , latent tuberculosis , tuberculosis , immunology , interferon γ , tuberculosis diagnosis , clinical practice , diagnostic test , immunologic tests , skin test , mycobacterium tuberculosis , interferon gamma , pathology , pediatrics , family medicine , immune system

Interferon-release assays (IGRAs) represent advances in tuberculosis immunology and evolutionary biology. IGRAs were designed to replace tuberculin skin test (TST) for the diagnosis of latent tuberculosis infection because of their logistical advantages and enhanced specificity over TST. Although IGRAs and TST have been useful in epidemiologic studies, they lack the sensitivity and reproducibility normally expected from diagnostic tests in clinical practice. In this review, we present an overview of the current recommendations and knowledge in the field and discuss practical approaches in areas of uncertainty related to discordant IGRA results.

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