A Randomized Study Comparing Combined Pneumococcal Conjugate and Polysaccharide Vaccination Schedules in Adults | Zendy

Rajeka Lazarus | Zendy; Elizabeth Clutterbuck | Zendy; LyMee Yu | Zendy; Jaclyn Bowman | Zendy; Elizabeth Bateman | Zendy; Linda Diggle | Zendy; Brian Angus | Zendy; Tim Peto | Zendy; Peter C. L. Beverley | Zendy; David Mant | Zendy; AJ Pollard | Zendy

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A Randomized Study Comparing Combined Pneumococcal Conjugate and Polysaccharide Vaccination Schedules in Adults

Author(s) -

Rajeka Lazarus,

Elizabeth Clutterbuck,

LyMee Yu,

Jaclyn Bowman,

Elizabeth Bateman,

Linda Diggle,

Brian Angus,

Tim Peto,

Peter C. L. Beverley,

David Mant,

AJ Pollard

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir003

Subject(s) - medicine , pneumococcal conjugate vaccine , immunogenicity , vaccination , immunology , immune system , streptococcus pneumoniae , microbiology and biotechnology , biology , antibiotics

The widely used 23-valent plain polysaccharide vaccine (23vP) has limited effectiveness, produces short-lived immune responses, and induces attenuated antibody production after subsequent challenge with pneumococcal vaccines. Our goal was to examine whether priming with the 7-valent pneumococcal conjugate vaccine (PCV7) could enhance the immunogenicity of 23vP for the PCV7 serotypes and to investigate whether 23vP induced hyporesponsiveness could be overcome using PCV7.

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