Influence of Donor Cytomegalovirus (CMV) Status on Severity of Viral Reactivation after Allogeneic Stem Cell Transplantation in CMV-Seropositive Recipients | Zendy

Floor Pietersma | Zendy; Suzanne van Dorp | Zendy; Monique C. Minnema | Zendy; Jürgen Kuball | Zendy; Ellen Meijer | Zendy; Rob Schuurman | Zendy; D. van Baarle | Zendy

Open Access

Influence of Donor Cytomegalovirus (CMV) Status on Severity of Viral Reactivation after Allogeneic Stem Cell Transplantation in CMV-Seropositive Recipients

Author(s) -

Floor Pietersma,

Suzanne van Dorp,

Monique C. Minnema,

Jürgen Kuball,

Ellen Meijer,

Rob Schuurman,

D. van Baarle

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/cir002

Subject(s) - serostatus , cytomegalovirus , medicine , immunology , betaherpesvirinae , transplantation , virology , human cytomegalovirus , virus , immunity , herpesviridae , viral disease , immune system , viral load

We investigated the role of donor cytomegalovirus (CMV) serostatus on reactivation of CMV infection in CMV-infected transplant recipients. Reactivation of CMV infection occurred more frequently in patients receiving a CMV-positive graft but was less severe than in patients receiving a CMV-negative graft. These data suggest roles for both virus as well as CMV-specific immunity present in the graft.

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