Prospective Identification of Congenital Cytomegalovirus Infection in Newborns Using Real-Time Polymerase Chain Reaction Assays in Dried Blood Spots | Zendy

Marianne LeruezVille | Zendy; Christelle VauloupFellous | Zendy; Sophie Couderc | Zendy; S. Parat | Zendy; C. Castel | Zendy; Véronique Avettand-Fènoël | Zendy; Tiffany Guilleminot | Zendy; L. GrangeotKeros | Zendy; Y. Ville | Zendy; Sophie Grabar | Zendy; J.-F. Magny | Zendy

Open Access

Prospective Identification of Congenital Cytomegalovirus Infection in Newborns Using Real-Time Polymerase Chain Reaction Assays in Dried Blood Spots

Author(s) -

Marianne LeruezVille,

Christelle VauloupFellous,

Sophie Couderc,

S. Parat,

C. Castel,

Véronique Avettand-Fènoël,

Tiffany Guilleminot,

L. GrangeotKeros,

Y. Ville,

Sophie Grabar,

J.-F. Magny

Publication year - 2011

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciq241

Subject(s) - medicine , asymptomatic , cytomegalovirus , population , polymerase chain reaction , human cytomegalovirus , gold standard (test) , dried blood , betaherpesvirinae , prospective cohort study , dried blood spot , newborn screening , urine , predictive value , pediatrics , immunology , viral disease , herpesviridae , virus , biology , biochemistry , chemistry , genetics , environmental health , chromatography , gene

Congenital cytomegalovirus (CMV) infection is a public health issue, and implementation of neonatal screening has been debated. Detection of CMV DNA by polymerase chain reaction (PCR) of dried blood spots (DBS) routinely collected for metabolic screening from all newborns has been proposed for congenital CMV infection screening. The goal of this study was to prospectively assess the performance of 2 CMV PCR assays of DBS for CMV neonatal screening in a selected population of neonates.

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