Open AccessRe-Evaluating the Treatment of Nongonococcal Urethritis: Emphasizing Emerging Pathogens-A Randomized Clinical Trial
Author(s) -
Jane R. Schwebke,
Anne Rompalo,
Stephanie N. Taylor,
Arlene C. Seña,
David H. Martín,
Laureen M Lopez,
Shelly Lensing,
J. Y. Lee
Publication year - 2010
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciq074
Subject(s) - azithromycin , urethritis , medicine , doxycycline , tinidazole , mycoplasma genitalium , chlamydia trachomatis , regimen , randomized controlled trial , chlamydia , trichomonas vaginalis , surgery , gastroenterology , gynecology , antibiotics , metronidazole , immunology , microbiology and biotechnology , biology
Nongonococcal urethritis (NGU) is a common chlamydia-associated syndrome in men; however, Trichomonas vaginalis and Mycoplasma genitalium are associated with its etiology and should be considered in approaches to therapy. We sought to determine whether the addition of tinidazole, an anti-trichomonal agent, to the treatment regimen would result in higher cure rates than those achieved with treatment with doxycycline or azithromycin alone. A secondary aim was to compare the efficacy of doxycycline therapy and with that of azithromycin therapy.