Serial Intervals and the Temporal Distribution of Secondary Infections within Households of 2009 Pandemic Influenza A (H1N1): Implications for Influenza Control Recommendations | Zendy

Christl A. Donnelly | Zendy; L. Finelli | Zendy; Simon Cauchemez | Zendy; Sonja J. Olsen | Zendy; Sonal R. Doshi | Zendy; Michael L. Jackson | Zendy; Ewan D. Kennedy | Zendy; Laurie Kamimoto | Zendy; Tiffany Marchbanks | Zendy; Oliver Morgan | Zendy; Minal Patel | Zendy; David L. Swerdlow | Zendy; Neil M. Ferguson | Zendy

Open Access

Serial Intervals and the Temporal Distribution of Secondary Infections within Households of 2009 Pandemic Influenza A (H1N1): Implications for Influenza Control Recommendations

Author(s) -

Christl A. Donnelly,

L. Finelli,

Simon Cauchemez,

Sonja J. Olsen,

Sonal R. Doshi,

Michael L. Jackson,

Ewan D. Kennedy,

Laurie Kamimoto,

Tiffany Marchbanks,

Oliver Morgan,

Minal Patel,

David L. Swerdlow,

Neil M. Ferguson

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciq028

Subject(s) - pandemic , medicine , transmission (telecommunications) , epidemiology , human mortality from h5n1 , h1n1 pandemic , isolation (microbiology) , influenza pandemic , influenza a virus , demography , pandemic influenza , limiting , covid-19 , h1n1 influenza , virus isolation , environmental health , virology , virus , disease , infectious disease (medical specialty) , biology , mechanical engineering , microbiology and biotechnology , sociology , electrical engineering , engineering

A critical issue during the 2009 influenza A (H1N1) pandemic was determining the appropriate duration of time individuals with influenza-like illness (ILI) should remain isolated to reduce onward transmission while limiting societal disruption. Ideally this is based on knowledge of the relative infectiousness of ill individuals at each point during the course of the infection. Data on 261 clinically apparent pH1N1 infector-infectee pairs in households, from 7 epidemiological studies conducted in the United States early in 2009, were analyzed to estimate the distribution of times from symptom onset in an infector to symptom onset in the household contacts they infect (mean, 2.9 days, not correcting for tertiary transmission). Only 5% of transmission events were estimated to take place >3 days after the onset of clinical symptoms among those ill with pH1N1 virus. These results will inform future recommendations on duration of isolation of individuals with ILI.

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