Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection With accumulation of mutations in a patient with poorly controlled Human Immunodeficiency Virus infection | Zendy

Tongai Maponga | Zendy; Montenique Jeffries | Zendy; Houriiyah Tegally | Zendy; Andrew D. Sutherland | Zendy; Eduan Wilkinson | Zendy; Richard Lessells | Zendy; Nokukhanya Msomi | Zendy; Gert U. van Zyl | Zendy; Túlio de Oliveira | Zendy; Wolfgang Preiser | Zendy

Open Access

Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection With accumulation of mutations in a patient with poorly controlled Human Immunodeficiency Virus infection

Author(s) -

Tongai Maponga,

Montenique Jeffries,

Houriiyah Tegally,

Andrew D. Sutherland,

Eduan Wilkinson,

Richard Lessells,

Nokukhanya Msomi,

Gert U. van Zyl,

Túlio de Oliveira,

Wolfgang Preiser

Publication year - 2022

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciac548

Subject(s) - medicine , virology , virus , coronavirus , human immunodeficiency virus (hiv) , respiratory system , immunology , betacoronavirus , covid-19 , pathology , disease , infectious disease (medical specialty)

A 22-year-old woman with uncontrolled advanced human immunodeficiency virus (HIV) infection was persistently infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) beta variant for 9 months, the virus accumulating >20 additional mutations. Antiretroviral therapy suppressed HIV and cleared SARS-CoV-2 within 6 to 9 weeks. Increased vigilance is warranted to benefit affected individuals and prevent the emergence of novel SARS-CoV-2 variants.

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