Open AccessPersistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection With accumulation of mutations in a patient with poorly controlled Human Immunodeficiency Virus infection
Author(s) -
Tongai Maponga,
Montenique Jeffries,
Houriiyah Tegally,
Andrew D. Sutherland,
Eduan Wilkinson,
Richard Lessells,
Nokukhanya Msomi,
Gert van Zyl,
Túlio de Oliveira,
Wolfgang Preiser
Publication year - 2022
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciac548
Subject(s) - medicine , virology , virus , coronavirus , human immunodeficiency virus (hiv) , respiratory system , immunology , betacoronavirus , covid-19 , pathology , disease , infectious disease (medical specialty)
A 22-year-old woman with uncontrolled advanced human immunodeficiency virus (HIV) infection was persistently infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) beta variant for 9 months, the virus accumulating >20 additional mutations. Antiretroviral therapy suppressed HIV and cleared SARS-CoV-2 within 6 to 9 weeks. Increased vigilance is warranted to benefit affected individuals and prevent the emergence of novel SARS-CoV-2 variants.