Effectiveness of Coronavirus Disease 2019 (COVID-19) mRNA Vaccines Against Infection During an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Beta (B.1.351) Variant in a Skilled Nursing Facility: Virginia, March–April 2021 | Zendy

Heidi L Moline | Zendy; Amelia A. Keaton | Zendy; Whitney Rice | Zendy; Jasmine Varghese | Zendy; Li Deng | Zendy; Ansley Waters | Zendy; Anna Barringer | Zendy; Devonne Winston | Zendy; Virgie Fields | Zendy; Kara Jacobs Slifka | Zendy; Jennifer R. Verani | Zendy; Stephanie J. Schrag | Zendy; John A. Jernigan | Zendy; Jacqueline E. Tate | Zendy; Katherine E. Fleming-Dutra | Zendy

Open Access

Effectiveness of Coronavirus Disease 2019 (COVID-19) mRNA Vaccines Against Infection During an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Beta (B.1.351) Variant in a Skilled Nursing Facility: Virginia, March–April 2021

Author(s) -

Heidi L Moline,

Amelia A. Keaton,

Whitney Rice,

Jasmine Varghese,

Li Deng,

Ansley Waters,

Anna Barringer,

Devonne Winston,

Virgie Fields,

Kara Jacobs Slifka,

Jennifer R. Verani,

Stephanie J. Schrag,

John A. Jernigan,

Jacqueline E. Tate,

Katherine E. Fleming-Dutra

Publication year - 2022

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciac526

Subject(s) - medicine , outbreak , context (archaeology) , covid-19 , coronavirus , vaccination , virology , betacoronavirus , disease , immunology , infectious disease (medical specialty) , biology , paleontology

In April 2021, we assessed mRNA vaccine effectiveness (VE) in the context of a COVID-19 outbreak in a skilled nursing facility. Among 28 cases, genomic sequencing was performed on 4 specimens on 4 different patients, and all were classified by sequence analysis as the Beta (B.1.351) variant. Adjusted VE among residents was 65% (95% confidence interval: 25-84%). These findings underscore the importance of vaccination for prevention of COVID-19 in skilled nursing facilities.

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