Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection | Zendy

Richard J. Fitzgerald | Zendy; Laura Dickinson | Zendy; Laura Else | Zendy; Tom Fletcher | Zendy; Colin Hale | Zendy; Alieu Amara | Zendy; Lauren Walker | Zendy; Sujan Dilly Penchala | Zendy; Rebecca Lyon | Zendy; Victoria Shaw | Zendy; William Greenhalf | Zendy; Katie Bullock | Zendy; Lara Lavelle-Langham | Zendy; Helen Reynolds | Zendy; Wendy Painter | Zendy; Wayne Holman | Zendy; Sean Ewings | Zendy; Gareth Griffiths | Zendy; Saye Khoo | Zendy

Open Access

Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Author(s) -

Richard J. Fitzgerald,

Laura Dickinson,

Laura Else,

Tom Fletcher,

Colin Hale,

Alieu Amara,

Lauren Walker,

Sujan Dilly Penchala,

Rebecca Lyon,

Victoria Shaw,

William Greenhalf,

Katie Bullock,

Lara Lavelle-Langham,

Helen Reynolds,

Wendy Painter,

Wayne Holman,

Sean Ewings,

Gareth Griffiths,

Saye Khoo

Publication year - 2022

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciac199

Subject(s) - prodrug , saliva , pharmacokinetics , nucleoside , medicine , nucleoside analogue , clinical trial , transmission (telecommunications) , covid-19 , coronavirus , respiratory system , pharmacology , gastroenterology , virology , chemistry , biochemistry , disease , infectious disease (medical specialty) , electrical engineering , engineering

ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at sites of SARS-CoV-2 transmission in twelve patients enrolled in AGILE CST-2 (NCT04746183). Saliva, nasal and tear concentrations were 3, 21 and 22% that of plasma. Saliva and nasal NHC concentrations were significantly correlated with plasma (p<0.0001).

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