Existence of immunological memory response in true sero-negative individuals post COVID-19 molecular diagnosis | Zendy

Yaniv Lustig | Zendy; Ella Mendelson | Zendy; Michal Mandelboim | Zendy; Asaf Biber | Zendy; E G Levin | Zendy; Carmit Cohen | Zendy; Gili RegevYochay | Zendy; Eli Schwartz | Zendy

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Existence of immunological memory response in true sero-negative individuals post COVID-19 molecular diagnosis

Author(s) -

Yaniv Lustig,

Ella Mendelson,

Michal Mandelboim,

Asaf Biber,

E G Levin,

Carmit Cohen,

Gili RegevYochay,

Eli Schwartz

Publication year - 2022

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciac196

Subject(s) - antibody response , covid-19 , antibody , immunology , false positive paradox , medicine , negative control , virology , mathematics , outbreak , disease , infectious disease (medical specialty) , statistics , traditional medicine

Approximately 1-8% of individuals do not develop antibodies following SARS-CoV-2 infection (sero-negatives). One BNT162b2 dose resulted in potent humoral response in 14 sero-negatives and 15 sero-positives, significantly higher than the response of 15 naïve-individuals, to two doses suggesting that COVID-19 provoked a memory response in individuals without detectable antibodies.

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