Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study | Zendy

Esin Kotiloglu-Karaa | Zendy; Beatrix Kele | Zendy; Raghavendran KulasegaranShylini | Zendy; Claire Broad | Zendy; Dola Owoyemi | Zendy; Joanne E. Martin | Zendy; Graham MacPhail | Zendy; Stamatina Iliodromiti | Zendy; Anna Riddell | Zendy; Eliza Alexander | Zendy; Teresa CutiñoMoguel | Zendy

Open Access

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study

Author(s) -

Esin Kotiloglu-Karaa,

Beatrix Kele,

Raghavendran KulasegaranShylini,

Claire Broad,

Dola Owoyemi,

Joanne E. Martin,

Graham MacPhail,

Stamatina Iliodromiti,

Anna Riddell,

Eliza Alexander,

Teresa CutiñoMoguel

Publication year - 2022

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciac173

Subject(s) - medicine , coronavirus , fetus , reverse transcription polymerase chain reaction , respiratory disease , respiratory system , placenta , covid-19 , immunohistochemistry , pathology , virology , lung , pregnancy , disease , gene , infectious disease (medical specialty) , biology , gene expression , genetics

We observed an increased frequency of massive perivillous fibrin deposition (MPFD) ,during the second COVID-19 pandemic wave dominated by the alpha variant of SARS-CoV-2. MPFD associated with 100% RT-PCR positivity for SARS-CoV-2 and detection by immunohistochemistry. The alpha variant was identified in all placentas with MPFD that could be sequenced.

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