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We observed an increased frequency of massive perivillous fibrin deposition (MPFD) ,during the second COVID-19 pandemic wave dominated by the alpha variant of SARS-CoV-2. MPFD associated with 100% RT-PCR positivity for SARS-CoV-2 and detection by immunohistochemistry. The alpha variant was identified in all placentas with MPFD that could be sequenced.

clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study