Trend in Sensitivity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Serology One Year After Mild and Asymptomatic Coronavirus Disease 2019 (COVID-19): Unpacking Potential Bias in Seroprevalence Studies | Zendy

Christopher R. Bailie | Zendy; Yeu Yang Tseng | Zendy; Louise Carolan | Zendy; Martyn Kirk | Zendy; Suellen Nicholson | Zendy; Annette Fox | Zendy; Sheena G. Sullivan | Zendy

Open Access

Trend in Sensitivity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Serology One Year After Mild and Asymptomatic Coronavirus Disease 2019 (COVID-19): Unpacking Potential Bias in Seroprevalence Studies

Author(s) -

Christopher R. Bailie,

Yeu Yang Tseng,

Louise Carolan,

Martyn Kirk,

Suellen Nicholson,

Annette Fox,

Sheena G. Sullivan

Publication year - 2022

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciac020

Subject(s) - seroprevalence , medicine , virology , asymptomatic , covid-19 , coronavirus , serology , pandemic , middle east respiratory syndrome coronavirus , immunology , disease , infectious disease (medical specialty) , antibody

A key aim of serosurveillance during the coronavirus disease 2019 (COVID-19) pandemic has been to estimate the prevalence of prior infection, by correcting crude seroprevalence against estimated test performance for polymerase chain reaction (PCR)-confirmed COVID-19. We show that poor generalizability of sensitivity estimates to some target populations may lead to substantial underestimation of case numbers.

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