A Higher Antibody Response Is Generated With a 6- to 7-Week (vs Standard) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Dosing Interval | Zendy

Brian Grunau | Zendy; Michael Asamoah-Boaheng | Zendy; Pascal M. Lavoie | Zendy; Mohammad Ehsanul Karim | Zendy; Tracy Kirkham | Zendy; Paul A. Demers | Zendy; Vilte Barakauskas | Zendy; Ana Márquez | Zendy; Agatha N. Jassem | Zendy; Sheila F. O’Brien | Zendy; Steven J. Drews | Zendy; Scott Haig | Zendy; Sheldon Cheskes | Zendy; David A. Goldfarb | Zendy

Open Access

A Higher Antibody Response Is Generated With a 6- to 7-Week (vs Standard) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Dosing Interval

Author(s) -

Brian Grunau,

Michael Asamoah-Boaheng,

Pascal M. Lavoie,

Mohammad Ehsanul Karim,

Tracy Kirkham,

Paul A. Demers,

Vilte Barakauskas,

Ana Márquez,

Agatha N. Jassem,

Sheila F. O’Brien,

Steven J. Drews,

Scott Haig,

Sheldon Cheskes,

David A. Goldfarb

Publication year - 2021

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciab938

Subject(s) - medicine , covid-19 , virology , betacoronavirus , coronavirus , respiratory system , antibody , immunology , severe acute respiratory syndrome coronavirus , dosing , outbreak , infectious disease (medical specialty) , disease

The optimal dosing interval for severe acute respiratory syndrome coronavirus 2 vaccines remains controversial. In this prospective study, we compared serology results of paramedics vaccinated with mRNA vaccines at the recommended short (17–28 days) vs long (42–49 days) interval. We found that a long dosing interval resulted in higher spike, receptor binding domain, and spike N terminal domain antibody concentrations.

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