False Coronavirus Disease 2019 Cases due to Contamination by Inactivated Virus Vaccine | Zendy

Kelvin KaiWang To | Zendy; Xin Li | Zendy; David Christopher Lung | Zendy; Jonathan Daniel Ip | Zendy; Wan-Mui Chan | Zendy; Allen WingHo Chu | Zendy; Cyril ChikYan Yip | Zendy; Jonathan Hon-Kwan Chen | Zendy; Rosana WingShan Poon | Zendy; HoiWah Tsoi | Zendy; Raymond WaiMan Lai | Zendy; WingKin To | Zendy; Lili Ren | Zendy; Mingkun Li | Zendy; Yunlong Cao | Zendy; Xiaoliang Sunney Xie | Zendy; DongYan Jin | Zendy; KwokYung Yuen | Zendy

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False Coronavirus Disease 2019 Cases due to Contamination by Inactivated Virus Vaccine

Author(s) -

Kelvin KaiWang To,

Xin Li,

David Christopher Lung,

Jonathan Daniel Ip,

Wan-Mui Chan,

Allen WingHo Chu,

Cyril ChikYan Yip,

Jonathan Hon-Kwan Chen,

Rosana WingShan Poon,

HoiWah Tsoi,

Raymond WaiMan Lai,

WingKin To,

Lili Ren,

Mingkun Li,

Yunlong Cao,

Xiaoliang Sunney Xie,

DongYan Jin,

KwokYung Yuen

Publication year - 2021

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciab684

Subject(s) - medicine , virology , coronavirus , antigenicity , polymerase chain reaction , vaccination , virus , reverse transcription polymerase chain reaction , disease , covid-19 , immunology , gene , antibody , infectious disease (medical specialty) , biology , genetics , pathology , messenger rna

A false-positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse-transcription polymerase chain reaction result can lead to unnecessary public health measures. We report 2 individuals whose respiratory specimens were contaminated by an inactivated SARS-CoV-2 vaccine strain (CoronaVac), likely at vaccination premises. Incidentally, whole genome sequencing of CoronaVac showed adaptive deletions on the spike protein, which do not result in observable changes of antigenicity.

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