Differences in Post-mRNA Vaccination Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Immunoglobulin G (IgG) Concentrations and Surrogate Virus Neutralization Test Response by Human Immunodeficiency Virus (HIV) Status and Type of Vaccine: A Matched Case-Control Observational Study | Zendy

Matthew A. Spinelli | Zendy; Michael J. Peluso | Zendy; Kara L. Lynch | Zendy; Cassandra Yun | Zendy; David V. Glidden | Zendy; Timothy J. Henrich | Zendy; Steven G. Deeks | Zendy; Monica Gandhi | Zendy

Open Access

Differences in Post-mRNA Vaccination Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Immunoglobulin G (IgG) Concentrations and Surrogate Virus Neutralization Test Response by Human Immunodeficiency Virus (HIV) Status and Type of Vaccine: A Matched Case-Control Observational Study

Author(s) -

Matthew A. Spinelli,

Michael J. Peluso,

Kara L. Lynch,

Cassandra Yun,

David V. Glidden,

Timothy J. Henrich,

Steven G. Deeks,

Monica Gandhi

Publication year - 2021

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciab1009

Subject(s) - medicine , immunology , vaccination , virology , antibody , virus , immunoglobulin g , coronavirus , covid-19 , disease , infectious disease (medical specialty)

Following SARS-CoV-2 mRNA vaccination, people living with HIV (PLWH) had lower surrogate virus neutralization test response (p=0.03) and a trend towards lower IgG response (p=0.08), particularly among those with lower CD4+T-cell counts and who received the BNT162b2 vaccine. Study of the impact of supplemental vaccine doses among PLWH is needed.

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