Latent Cytomegalovirus Infection and Previous Capsular Polysaccharide Vaccination Predict Poor Vaccine Responses in Older Adults, Independent of Chronic Kidney Disease | Zendy

Nadezhda Wall | Zendy; Alexandra Godlee | Zendy; Daniel Geh | Zendy; Nick D. Jones | Zendy; Sian Faustini | Zendy; Ruth Harvey | Zendy; Rebecca Penn | Zendy; Dimitrios Chanouzas | Zendy; Peter Nightingale | Zendy; Matthew K. O’Shea | Zendy; Alex Richter | Zendy; Paul Moss | Zendy; Adam F. Cunningham | Zendy; Lorraine Harper | Zendy

Open Access

Latent Cytomegalovirus Infection and Previous Capsular Polysaccharide Vaccination Predict Poor Vaccine Responses in Older Adults, Independent of Chronic Kidney Disease

Author(s) -

Nadezhda Wall,

Alexandra Godlee,

Daniel Geh,

Nick D. Jones,

Sian Faustini,

Ruth Harvey,

Rebecca Penn,

Dimitrios Chanouzas,

Peter Nightingale,

Matthew K. O’Shea,

Alex Richter,

Paul Moss,

Adam F. Cunningham,

Lorraine Harper

Publication year - 2021

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciab078

Subject(s) - medicine , vaccination , kidney disease , immunology , immune system

Patients with chronic kidney disease (CKD) are more prone to severe infection. Vaccination is a key strategy to reduce this risk. Some studies suggest vaccine efficacy may be reduced in patients with CKD, despite preserved maintenance of long-term responses to some pathogens and vaccines. Here, we investigated immune responses to 2 vaccines in patients with CKD to identify predictors of immunological responsiveness.

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