Growth Hormone Releasing Hormone Reduces Circulating Markers of Immune Activation in Parallel with Effects on Hepatic Immune Pathways in Individuals with HIV-infection and Nonalcoholic Fatty Liver Disease | Zendy

Takara L. Stanley | Zendy; Lindsay T. Fourman | Zendy; Lai Ping Wong | Zendy; Ruslan I. Sadreyev | Zendy; James M. Billingsley | Zendy; Meghan N. Feldpausch | Zendy; Isabel Zheng | Zendy; Chelsea S. Pan | Zendy; Autumn Boutin | Zendy; Hang Lee | Zendy; Kathleen E. Corey | Zendy; Martin Torriani | Zendy; David E. Kleiner | Zendy; Raymond T. Chung | Zendy; Colleen Hadigan | Zendy; Steven Grinspoon | Zendy

Open Access

Growth Hormone Releasing Hormone Reduces Circulating Markers of Immune Activation in Parallel with Effects on Hepatic Immune Pathways in Individuals with HIV-infection and Nonalcoholic Fatty Liver Disease

Author(s) -

Takara L. Stanley,

Lindsay T. Fourman,

Lai Ping Wong,

Ruslan I. Sadreyev,

James M. Billingsley,

Meghan N. Feldpausch,

Isabel Zheng,

Chelsea S. Pan,

Autumn Boutin,

Hang Lee,

Kathleen E. Corey,

Martin Torriani,

David E. Kleiner,

Raymond T. Chung,

Colleen Hadigan,

Steven Grinspoon

Publication year - 2021

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciab019

Subject(s) - immune system , nonalcoholic fatty liver disease , medicine , hormone , immunology , disease , fatty liver

The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis modulates critical metabolic pathways; however, little is known regarding effects of augmenting pulsatile GH secretion on immune function in humans. This study used proteomics and gene set enrichment analysis to assess effects of a GH releasing hormone (GHRH) analog, tesamorelin, on circulating immune markers and liver tissue in people with human immunodeficiency virus (HIV) (PWH) and nonalcoholic fatty liver disease (NAFLD).

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