Evidence for the Use of Triage, Respiratory Isolation, and Effective Treatment to Reduce the Transmission of Mycobacterium Tuberculosis in Healthcare Settings: A Systematic Review | Zendy

Aaron S Karat | Zendy; Meghann Gregg | Zendy; Hannah E Barton | Zendy; María Calderón | Zendy; Jayne Ellis | Zendy; Jane Falconer | Zendy; Indira Govender | Zendy; Rebecca C. Harris | Zendy; Mpho Tlali | Zendy; David Moore | Zendy; Katherine Fielding | Zendy

Open Access

Evidence for the Use of Triage, Respiratory Isolation, and Effective Treatment to Reduce the Transmission of Mycobacterium Tuberculosis in Healthcare Settings: A Systematic Review

Author(s) -

Aaron S Karat,

Meghann Gregg,

Hannah E Barton,

María Calderón,

Jayne Ellis,

Jane Falconer,

Indira Govender,

Rebecca C. Harris,

Mpho Tlali,

David Moore,

Katherine Fielding

Publication year - 2020

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciaa720

Subject(s) - medicine , tuberculosis , isolation (microbiology) , triage , transmission (telecommunications) , mycobacterium tuberculosis , infection control , intensive care medicine , health care , incidence (geometry) , disease , environmental health , emergency medicine , pathology , bioinformatics , physics , optics , economic growth , electrical engineering , economics , biology , engineering

Evidence is limited for infection prevention and control (IPC) measures reducing Mycobacterium tuberculosis (MTB) transmission in health facilities. This systematic review, 1 of 7 commissioned by the World Health Organization to inform the 2019 update of global tuberculosis (TB) IPC guidelines, asked: do triage and/or isolation and/or effective treatment of TB disease reduce MTB transmission in healthcare settings? Of 25 included articles, 19 reported latent TB infection (LTBI) incidence in healthcare workers (HCWs; absolute risk reductions 1%-21%); 5 reported TB disease incidence in HCWs (no/slight [high TB burden] or moderate [low burden] reduction) and 2 in human immunodeficiency virus-positive in-patients (6%-29% reduction). In total, 23/25 studies implemented multiple IPC measures; effects of individual measures could not be disaggregated. Packages of IPC measures appeared to reduce MTB transmission, but evidence for effectiveness of triage, isolation, or effective treatment, alone or in combination, was indirect and low quality. Harmonizing study designs and reporting frameworks will permit formal data syntheses and facilitate policy making.

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