Open AccessSources of Multidrug Resistance in Patients With Previous Isoniazid-Resistant Tuberculosis Identified Using Whole Genome Sequencing: A Longitudinal Cohort Study
Author(s) -
Srinivasan Vijay,
Vu Thi Ngoc Ha,
Dao Nguyen Vinh,
Phan Vuong Khac Thai,
Đặng Thị Minh Hà,
Nguyễn Hữu Lân,
Hoang Thanh Hai,
A Sarah Walker,
Do D. A. Thu,
Sarah J. Dunstan,
Guy Thwaites,
Philip Ashton,
Maxine Caws,
Nguyễn Thụy Thương Thương
Publication year - 2020
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciaa254
Subject(s) - isoniazid , tuberculosis , medicine , drug resistance , mycobacterium tuberculosis , rifampicin , multiple drug resistance , single nucleotide polymorphism , virology , biology , microbiology and biotechnology , genetics , genotype , pathology , gene
Meta-analysis of patients with isoniazid-resistant tuberculosis (TB) given standard first-line anti-TB treatment indicated an increased risk of multidrug-resistant TB (MDR-TB) emerging (8%), compared to drug-sensitive TB (0.3%). Here we use whole genome sequencing (WGS) to investigate whether treatment of patients with preexisting isoniazid-resistant disease with first-line anti-TB therapy risks selecting for rifampicin resistance, and hence MDR-TB.
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