Open AccessInflammatory Phenotypes Predict Changes in Arterial Stiffness Following Antiretroviral Therapy Initiation
Author(s) -
Christine Kelly,
Willard Tinago,
Dagmar G. Alber,
Patricia Hunter,
Natasha Luckhurst,
Jake Connolly,
Francesca Arrigoni,
Alejandro Garcia Abner,
Ralph Kamngona,
Irene Sheha,
Mishek Chammudzi,
Kondwani Jambo,
Jane Mallewa,
Alicja Rapala,
Robert S. Heyderman,
Patrick Mallon,
Henry C. Mwandumba,
A. Sarah Walker,
Nigel Klein,
Saye Khoo
Publication year - 2020
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciaa186
Subject(s) - medicine , inflammation , pulse wave velocity , arterial stiffness , immunology , proinflammatory cytokine , blood pressure
Inflammation drives vascular dysfunction in HIV, but in low-income settings causes of inflammation are multiple, and include infectious and environmental factors. We hypothesized that patients with advanced immunosuppression could be stratified into inflammatory phenotypes that predicted changes in vascular dysfunction on ART.
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