Open AccessIncreased Body Mass Index and Type 2 Diabetes Are the Main Predictors of Nonalcoholic Fatty Liver Disease and Advanced Fibrosis in Liver Biopsies of Patients With Human Immunodeficiency Virus Monoinfection
Author(s) -
James Maurice,
Robert Goldin,
Andrew Hall,
Jennifer C. Price,
Giada Sebastiani,
Caryn G. Morse,
Laura Iogna Prat,
Hugo Perazzo,
Lucy Garvey,
Patrick Ingiliz,
Giovanni Guaraldi,
Emmanuel Tsochatzis,
Maud Lemoine
Publication year - 2020
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1093/cid/ciaa1302
Subject(s) - medicine , nonalcoholic fatty liver disease , fibrosis , gastroenterology , cirrhosis , liver biopsy , fatty liver , diabetes mellitus , body mass index , steatohepatitis , liver disease , type 2 diabetes , disease , biopsy , pathology , endocrinology
Liver disease is an important cause of morbidity and mortality in people living with human immunodeficiency virus (PLWH), of which nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause. There are limited data investigating NAFLD in HIV monoinfection and histologically defined disease. We aimed to identify who is at risk of fibrosis, NAFLD, and nonalcoholic steatohepatitis (NASH) among PLWH and explore the diagnostic accuracy of noninvasive markers of fibrosis.
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