Liquid Chromatographic Chiral Separation of Acenocoumarol and Its Hemiketal Form | Zendy

Aicha Kraimi | Zendy; Nasser Belboukhari | Zendy; Khaled Sekkoum | Zendy; Abdelkrim Cheriti | Zendy; Hassan Y. AboulEnein | Zendy

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Liquid Chromatographic Chiral Separation of Acenocoumarol and Its Hemiketal Form

Author(s) -

Aicha Kraimi,

Nasser Belboukhari,

Khaled Sekkoum,

Abdelkrim Cheriti,

Hassan Y. AboulEnein

Publication year - 2017

Publication title -

journal of chromatographic science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.362

H-Index - 56

eISSN - 1945-239X

pISSN - 0021-9665

DOI - 10.1093/chromsci/bmx061

Subject(s) - chemistry , acenocoumarol , chromatography , high performance liquid chromatography , cellulose , organic chemistry , warfarin , medicine , cardiology , atrial fibrillation

Acenocoumarol, an anticoagulant drug, was separated successfully using polysaccharide-based chiral stationary phases columns namely Cellulose Chiralpak® IB and Chiralcel® OD, using various normal mobile phases by high-performance liquid chromatography. However, the appearance of four well separated peaks confirmed the presence of the hemiketal form of 4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one.

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