Ethyl Lactate as a Greener Alternative to Acetonitrile in RPLC: A Realistic Appraisal | Zendy

Florina Micăle | Zendy; Florin Albu | Zendy; Emilia Elena Iorgulescu | Zendy; Andrei Medvedovici | Zendy; Florentin Tache | Zendy

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Ethyl Lactate as a Greener Alternative to Acetonitrile in RPLC: A Realistic Appraisal

Author(s) -

Florina Micăle,

Florin Albu,

Emilia Elena Iorgulescu,

Andrei Medvedovici,

Florentin Tache

Publication year - 2015

Publication title -

journal of chromatographic science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.362

H-Index - 56

eISSN - 1945-239X

pISSN - 0021-9665

DOI - 10.1093/chromsci/bmv077

Subject(s) - chemistry , acetonitrile , ethyl lactate , elution , chromatography , solvent , extraction (chemistry) , chromatographic separation , ethyl acetate , high performance liquid chromatography , reversed phase chromatography , organic chemistry

Appropriate substitution of acetonitrile (ACN) in mobile phases for reversed-phase liquid chromatography (RPLC) by low toxicity, ecologically friendly alternative solvents emerges as a greener approach in separation sciences. Ethyl lactate is considered as a green solvent in organic synthesis, industrial extraction processes and many other applicative fields. Its ability to substitute ACN in mobile phases for RPLC applications was barely investigated. The feasibility of such a replacement was tested for the separation of the mixture of 16 polycyclic aromatic hydrocarbons listed by the Environmental Protection Agency. The analytical approach was found to be achievable, with some compromises in terms of elution order, peak efficiency and UV detectability. Thermodynamic aspects of the chromatographic process were also comparatively assessed. Correlations between the elution order and some molecular descriptors were also discussed.

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