Preparation and Enantioseparation Characteristics of a Novel β-Cyclodextrin Derivative Chiral Stationary Phase in High-Performance Liquid Chromatography | Zendy

Jie Zhou | Zendy; Wenjuan Pei | Zendy; Xuxia Zheng | Zendy; Suzhen Zhao | Zendy; Zhenzhong Zhang | Zendy

Open Access

Preparation and Enantioseparation Characteristics of a Novel β-Cyclodextrin Derivative Chiral Stationary Phase in High-Performance Liquid Chromatography

Author(s) -

Jie Zhou,

Wenjuan Pei,

Xuxia Zheng,

Suzhen Zhao,

Zhenzhong Zhang

Publication year - 2014

Publication title -

journal of chromatographic science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.362

H-Index - 56

eISSN - 1945-239X

pISSN - 0021-9665

DOI - 10.1093/chromsci/bmu099

Subject(s) - chemistry , enantiomer , cyclodextrin , silica gel , chromatography , derivative (finance) , high performance liquid chromatography , methanol , aqueous solution , phase (matter) , chlorine , chiral derivatizing agent , chiral column chromatography , organic chemistry , financial economics , economics

A novel cyclodextrin (CD) derivative mono(6(A)-N-allylamino-6(A)-deoxy)per-3-chlorine-4-methyl-phenylcarbamoylated-β-CD was synthesized and chemically immobilized onto the surface of γ-mercaptopropyl-functionalized silica gel step by step. The products were all purified and characterized and then got a substance with definitional structure. This chiral stationary phase (CSP) of 3-chlorine-4-methyl-phenylcarbamoylated-β-CD bonded on silica gel exhibited excellent separation capability for several chiral compounds in high-performance liquid chromatography. In the enantiomeric separations of five racemates with a mixture of methanol and aqueous KH2PO4 buffer as the mobile phase, this CSP presented good chiral recognition performance.

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