Characterization and Comparison of Methacrylic Acid with 2-Acrylamido-2-methyl-1-propanesulfonic Acid in the Preparation of Monolithic Column for Capillary Electrochromatography | Zendy

Daisuke Horiguchi | Zendy; Kaname Ohyama | Zendy; Tomoko Masunaga | Zendy; Yoshiko Fujita | Zendy; Marwa F. B. Ali | Zendy; Naoya Kishikawa | Zendy; Naotaka Kuroda | Zendy

Open Access

Characterization and Comparison of Methacrylic Acid with 2-Acrylamido-2-methyl-1-propanesulfonic Acid in the Preparation of Monolithic Column for Capillary Electrochromatography

Author(s) -

Daisuke Horiguchi,

Kaname Ohyama,

Tomoko Masunaga,

Yoshiko Fujita,

Marwa F. B. Ali,

Naoya Kishikawa,

Naotaka Kuroda

Publication year - 2012

Publication title -

journal of chromatographic science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.362

H-Index - 56

eISSN - 1945-239X

pISSN - 0021-9665

DOI - 10.1093/chromsci/bms158

Subject(s) - chemistry , capillary electrochromatography , monolithic hplc column , methacrylic acid , chromatography , electrochromatography , characterization (materials science) , capillary action , capillary electrophoresis , high performance liquid chromatography , polymer , copolymer , organic chemistry , nanotechnology , materials science , composite material

Butyl methacrylate (BMA)-ethylene dimethacrylate (EDMA)-methacrylic acid (MAA) and BMA-EDMA-2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) monolithic columns were prepared by varying the percentage of ionic monomers for capillary electrochromatography. Monolithic columns with a higher content of ionic monomers provided better column efficiency, and the performance of BMA-EDMA-MAA monoliths was better than BMA-EDMA-AMPS. To characterize and optimize BMA-EDMA-MAA monoliths, the effects of the content of cross-linker and the total monomer in the polymerization mixture on column performance were also studied. Plate heights of 8.2 µm for the unretained solute (thiourea) and 12.6 µm for the retained solute (naphthalene) were achieved with a monolithic column using 2.5% MAA (Column I).

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