In Vitro Characterization of Borneol Metabolites by GC--MS Upon Incubation with Rat Liver Microsomes | Zendy

Rongrong Zhang | Zendy; Chang Liu | Zendy; Tao Huang | Zendy; Wang Ning-sheng | Zendy; Suiqing Mi | Zendy

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In Vitro Characterization of Borneol Metabolites by GC--MS Upon Incubation with Rat Liver Microsomes

Author(s) -

Rongrong Zhang,

Chang Liu,

Tao Huang,

Wang Ning-sheng,

Suiqing Mi

Publication year - 2008

Publication title -

journal of chromatographic science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.362

H-Index - 56

eISSN - 1945-239X

pISSN - 0021-9665

DOI - 10.1093/chromsci/46.5.419

Subject(s) - chemistry , borneol , microsome , chromatography , in vitro , incubation , microsoma , gas chromatography–mass spectrometry , biochemistry , mass spectrometry , medicine , alternative medicine , pathology , traditional chinese medicine

The metabolism of borneol is studied by the analysis of incubations of in vitro-prepared rat liver microsomes. A sensitive gas chromatography (GC)-mass spectrometry (MS) method is developed for the identification of borneol and its metabolites. Four novel metabolites, which have not previously been reported, are isolated and confirmed by comparison of the GC-MS method. The biotransformation pathway of borneol in rat liver microsomes is proposed based on the in vitro results.

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