Open AccessDistinct Neural Substrates for Semantic Knowledge and Naming in the Temporoparietal Network
Author(s) -
Benno Gesierich,
Jorge Jovicich,
Marianna Riello,
Michela Adriani,
Alessia Monti,
Valentina Brentari,
Simon Robinson,
Stephen M. Wilson,
Scott L. Fairhall,
Maria Luisa GornoTempini
Publication year - 2011
Publication title -
cerebral cortex
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.694
H-Index - 250
eISSN - 1460-2199
pISSN - 1047-3211
DOI - 10.1093/cercor/bhr286
Subject(s) - semantic memory , functional magnetic resonance imaging , temporal lobe , computer science , covert , temporoparietal junction , semantics (computer science) , neuroimaging , temporal cortex , artificial intelligence , psychology , cognition , neuroscience , linguistics , prefrontal cortex , philosophy , epilepsy , programming language
Patients with anterior temporal lobe (ATL) lesions show semantic and lexical retrieval deficits, and the differential role of this area in the 2 processes is debated. Functional neuroimaging in healthy individuals has not clarified the matter because semantic and lexical processes usually occur simultaneously and automatically. Furthermore, the ATL is a region challenging for functional magnetic resonance imaging (fMRI) due to susceptibility artifacts, especially at high fields. In this study, we established an optimized ATL-sensitive fMRI acquisition protocol at 4 T and applied an event-related paradigm to study the identification (i.e., association of semantic biographical information) of celebrities, with and without the ability to retrieve their proper names. While semantic processing reliably activated the ATL, only more posterior areas in the left temporal and temporal-parietal junction were significantly modulated by covert lexical retrieval. These results suggest that within a temporoparietal network, the ATL is relatively more important for semantic processing, and posterior language regions are relatively more important for lexical retrieval.