Regulation of Stroke-Induced Neurogenesis in Adult Brain—Recent Scientific Progress | Zendy

Zaal Kokaia | Zendy; Pär Thored | Zendy; Andreas Arvidsson | Zendy; Olle Lindvall | Zendy

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Regulation of Stroke-Induced Neurogenesis in Adult Brain—Recent Scientific Progress

Author(s) -

Zaal Kokaia,

Pär Thored,

Andreas Arvidsson,

Olle Lindvall

Publication year - 2006

Publication title -

cerebral cortex

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.694

H-Index - 250

eISSN - 1460-2199

pISSN - 1047-3211

DOI - 10.1093/cercor/bhj174

Subject(s) - neurogenesis , neuroscience , stroke (engine) , striatum , mechanism (biology) , mammalian brain , subventricular zone , psychology , biology , neural stem cell , dopamine , stem cell , mechanical engineering , philosophy , epistemology , engineering , genetics

Stroke induced by middle cerebral artery occlusion in adult rodents induces the formation of new neurons in the damaged striatum, a region that normally does not show neurogenesis. Here we describe recent findings on the regulation of neurogenesis after stroke, in particular regarding the duration of the neurogenic response and the influence of age, as well as the molecular mechanisms influencing migration and survival of the new neurons. We also discuss some crucial issues that need to be addressed in the further exploration of this potential self-repair mechanism after damage to the adult brain.

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