Ringo, Doty, Demeter and Simard, Cerebral Cortex 1994;4:331-343: A Proof of the Need for the Spatial Clustering of Interneuronal Connections to Enhance Cortical Computation

It has been argued that an important principle driving the organization of the cerebral cortex towards local processing has been the need to decrease time lost to interneuronal conduction delay. In this paper, I show for a simplified model of the cerebral cortex, using analytical means, that if interneuronal conduction time increases proportional to interneuronal distance, then the only way to increase the numbers of synaptic events occurring in a fixed finite time period is to spatially cluster interneuronal connections.