Determination of Vitamin D and Its Metabolites in Human Brain Using an Ultra-Pressure LC–Tandem Mass Spectra Method | Zendy

Xueyan Fu | Zendy; Gregory G. Dolnikowski | Zendy; William B. Patterson | Zendy; Bess DawsonHughes | Zendy; Tong Zheng | Zendy; Martha Clare Morris | Zendy; Thomas Holland | Zendy; Sarah L. Booth | Zendy

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Determination of Vitamin D and Its Metabolites in Human Brain Using an Ultra-Pressure LC–Tandem Mass Spectra Method

Author(s) -

Xueyan Fu,

Gregory G. Dolnikowski,

William B. Patterson,

Bess DawsonHughes,

Tong Zheng,

Martha Clare Morris,

Thomas Holland,

Sarah L. Booth

Publication year - 2019

Publication title -

current developments in nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.904

H-Index - 14

ISSN - 2475-2991

DOI - 10.1093/cdn/nzz074

Subject(s) - vitamin , derivatization , corpus callosum , chemistry , human brain , cerebellum , vitamin d and neurology , cortex (anatomy) , cerebral cortex , medicine , cholecalciferol , endocrinology , chromatography , biochemistry , mass spectrometry , pathology , biology , neuroscience

To the best of our knowledge, this study is the first report of the measurement of concentrations of vitamin D metabolites in human brain. This validated method can be applied to postmortem studies to obtain accurate information about the presence and role of vitamin D and its metabolites in human brain and neurodegenerative diseases.

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