Molecular mechanisms underlying the divergent roles of SPARC in human carcinogenesis | Zendy

Ganji Purnachandra Nagaraju | Zendy; Ranadheer Dontula | Zendy; Bassel F. ElRayes | Zendy; Sajani S. Lakka | Zendy

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Molecular mechanisms underlying the divergent roles of SPARC in human carcinogenesis

Author(s) -

Ganji Purnachandra Nagaraju,

Ranadheer Dontula,

Bassel F. ElRayes,

Sajani S. Lakka

Publication year - 2014

Publication title -

carcinogenesis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.688

H-Index - 204

eISSN - 1460-2180

pISSN - 0143-3334

DOI - 10.1093/carcin/bgu072

Subject(s) - extracellular matrix , angiogenesis , carcinogenesis , cell adhesion , microbiology and biotechnology , biology , cell growth , cell migration , integrin , cancer cell , cell adhesion molecule , cell signaling , signal transduction , tumor microenvironment , cell , cancer , cancer research , biochemistry , genetics

Communication between the cell and its surrounding environment, consisting of proteinaceous (non-living material) and extracellular matrix (ECM), is important for biophysiological and chemical signaling. This signaling results in a range of cellular activities, including cell division, adhesion, differentiation, invasion, migration and angiogenesis. The ECM non-structural secretory glycoprotein called secreted protein, acidic and rich in cysteine (SPARC), plays a significant role in altering cancer cell activity and the tumor's microenvironment (TME). However, the role of SPARC in cancer research has been the subject of controversy. This review mainly focuses on recent advances in understanding the contradictory nature of SPARC in relation to ECM assembly, cancer cell proliferation, adhesion, migration, apoptosis and tumor growth.

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