Open AccessFyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer
Author(s) -
Zhiyu Chen,
Lei Cai,
Jun Zhu,
Min Chen,
Jian Chen,
Zhihua Li,
Xiang-De Liu,
Shuguang Wang,
Ping Bie,
Peng Jiang,
Jiahong Dong,
Xiaowu Li
Publication year - 2011
Publication title -
carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.688
H-Index - 204
eISSN - 1460-2180
pISSN - 0143-3334
DOI - 10.1093/carcin/bgr088
Subject(s) - fyn , gene knockdown , apoptosis , pancreatic cancer , cancer research , rna interference , microbiology and biotechnology , cancer cell , downregulation and upregulation , chemistry , heterogeneous nuclear ribonucleoprotein , biology , kinase , rna splicing , cancer , proto oncogene tyrosine protein kinase src , rna , biochemistry , gene , genetics
The Src family kinase Fyn, heterogenous nuclear ribonucleoprotein (HnRNP) A2B1 and Sam68 are thought to be associated with the metastasis of tumors, but their roles in the regulation of apoptosis remain unclear. This study investigated the role of Fyn and its potential relationship with HnRNPA2B1 and Sam68 in the regulation of apoptosis in pancreatic cancer. Experimental design. We examined both the activity of Fyn and the expression of HnRNPA2B1 in human pancreatic cancer tissues and systematically investigated the apoptotic mechanisms induced by Fyn activity using multiple experimental approaches.