Emerging role of KLF4 in human gastrointestinal cancer | Zendy

Daoyan Wei | Zendy; Masashi Kanai | Zendy; Suyun Huang | Zendy; Keping Xie | Zendy

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Emerging role of KLF4 in human gastrointestinal cancer

Author(s) -

Daoyan Wei,

Masashi Kanai,

Suyun Huang,

Keping Xie

Publication year - 2005

Publication title -

carcinogenesis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.688

H-Index - 204

eISSN - 1460-2180

pISSN - 0143-3334

DOI - 10.1093/carcin/bgi243

Subject(s) - klf4 , carcinogenesis , krüppel , colorectal cancer , cancer , gastrointestinal tract , cancer research , biology , medicine , transcription factor , genetics , gene , sox2

Recent analyses revealed that Krüppel-like factors (KLFs) play important roles in both normal development and carcinogenesis. Of the 16 known KLFs, KLF4 has been shown to be involved in the regulation of proliferation, differentiation and tumorigenesis of gastrointestinal tract epithelium. Clinical, experimental and mechanistic findings indicate that KLF4 is a bona fide tumor suppressor for both gastric and colorectal cancers. In this review, we summarize how this growing area of research has formed and the challenging new frontiers for better understanding of the oncogenic potential of the KLFs.

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