Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. | Zendy

Patricia L. Opresko | Zendy; WenHsing Cheng | Zendy; Cayetano von Kobbe | Zendy; Jeanine A. Harrigan | Zendy; Vilhelm A. Bohr | Zendy

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Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.

Author(s) -

Patricia L. Opresko,

WenHsing Cheng,

Cayetano von Kobbe,

Jeanine A. Harrigan,

Vilhelm A. Bohr

Publication year - 2003

Publication title -

carcinogenesis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.688

H-Index - 204

eISSN - 1460-2180

pISSN - 0143-3334

DOI - 10.1093/carcin/bgg034

Subject(s) - werner syndrome , genome instability , premature aging , progeria , dna repair , chromosome instability , disease , cataracts , cancer , biology , senescence , accelerated aging , genetics , medicine , dna damage , gerontology , dna , bioinformatics , gene , chromosome , chemistry , helicase , rna

Werner syndrome (WS) is a hallmark premature aging disease, in which the patients appear much older than their chronological age, and exhibit many of the clinical signs and symptoms of normal aging at an early stage in life. They develop many age-associated diseases early in life including atherosclerosis, osteoporosis, cataracts and display a high incidence of cancer. WS is also marked by increased genomic instability, manifested as chromosomal alterations. Characterization and study of the Werner protein (WRN) suggests that it participates in several important DNA metabolic pathways, and that its primary function may be in DNA repair processes. Thus, the WRN protein represents an important link between defective DNA repair and the processes related to aging and cancer.

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