Variability and regulation of O6-alkylguanine-DNA alkyltransferase | Zendy

G.P. Margison | Zendy

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Variability and regulation of O6-alkylguanine-DNA alkyltransferase

Author(s) -

G.P. Margison

Publication year - 2003

Publication title -

carcinogenesis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.688

H-Index - 204

eISSN - 1460-2180

pISSN - 0143-3334

DOI - 10.1093/carcin/bgg005

Subject(s) - dna , carcinogen , cancer research , biology , dna damage , microbiology and biotechnology , chemistry , biochemistry

O(6)-Alkylguanine-DNA alkyltransferase (ATase) confers resistance to many of the biological effects of certain classes of alkylating agents by repairing the DNA lesions responsible. The role of ATase in the mutagenic and toxic effects of the carcinogenic and antitumour alkylating agents are of interest in relation to the prevention and treatment of cancer in man. In this commentary we specifically focus on the variation in ATase levels and our current understanding of the factors involved in the regulation of ATase expression.

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