Open AccessInduction of AP-1 activity by perillyl alcohol in breast cancer cells
Author(s) -
Yoshiko Satomi,
Shigeki Miyamoto,
Michael N. Gould
Publication year - 1999
Publication title -
carcinogenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.688
H-Index - 204
eISSN - 1460-2180
pISSN - 0143-3334
DOI - 10.1093/carcin/20.10.1957
Subject(s) - kinase , apoptosis , cell cycle , gene expression , monoterpene , cancer research , protein kinase a , gene , phosphorylation , signal transduction , chemistry , cyclin dependent kinase 4 , transcriptional activity , cell growth , biology , microbiology and biotechnology , biochemistry , mitogen activated protein kinase kinase
Monoterpenes display chemopreventive and therapeutic activity in rat mammary tumor models. Monoterpenes can also inhibit cell growth and induce apoptosis of cultured cells. In this study, the monoterpene perillyl alcohol (POH) was found to induce transient expression of the c-jun and c-fos genes transcriptionally. POH also transiently induced phosphorylation of c-Jun protein. These events were associated with transcriptional activation of an AP-1-dependent reporter gene. These results suggest that POH might affect c-Jun activity via the Jun N-terminal kinase/stress-activated protein kinase pathway and modulate expression of AP-1 target genes.