Attenuating the DNA damage response to double-strand breaks restores function in models of CNS neurodegeneration | Zendy

Richard I. Tuxworth | Zendy; Matthew J. Taylor | Zendy; Ane Martín Anduaga | Zendy; Alaa Hussien-Ali | Zendy; Sotiroula Chatzimatthaiou | Zendy; Joanne Longland | Zendy; Adam Thompson | Zendy; Sharif Almutiri | Zendy; Pavlos Alifragis | Zendy; Charalambos P. Kyriacou | Zendy; Boris Kysela | Zendy; Zubair Ahmed | Zendy

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Attenuating the DNA damage response to double-strand breaks restores function in models of CNS neurodegeneration

Author(s) -

Richard I. Tuxworth,

Matthew J. Taylor,

Ane Martín Anduaga,

Alaa Hussien-Ali,

Sotiroula Chatzimatthaiou,

Joanne Longland,

Adam Thompson,

Sharif Almutiri,

Pavlos Alifragis,

Charalambos P. Kyriacou,

Boris Kysela,

Zubair Ahmed

Publication year - 2019

Publication title -

brain communications

Language(s) - English

Resource type - Journals

ISSN - 2632-1297

DOI - 10.1093/braincomms/fcz005

Subject(s) - neuroprotection , neurodegeneration , dna damage , biology , neuroscience , spiral ganglion , microbiology and biotechnology , dorsal root ganglion , neurite , dna repair , spinal cord , medicine , pathology , dna , genetics , cochlea , in vitro , disease

DNA double strand breaks feature in neurological disorders, including many forms of neurodegeneration, stroke and acute neurotrauma. Tuxworth et al. show that inhibiting the DNA damage sensing response is neuroprotective, axon regenerative and improves functional recovery in models of neurodegeneration and optic nerve and spinal cord injury.

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