Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis | Zendy

Sebastian Herich | Zendy; Tilman SchneiderHohendorf | Zendy; Astrid Rohlmann | Zendy; Maryam Khaleghi Ghadiri | Zendy; Andreas SchulteMecklenbeck | Zendy; Lisa Zondler | Zendy; Claudia Janoschka | Zendy; Patrick Ostkamp | Zendy; Jannis Richter | Zendy; Johanna Breuer | Zendy; Stoyan Dimitrov | Zendy; HansGeorg Rammensee | Zendy; Oliver Grauer | Zendy; Luisa Klotz | Zendy; Catharina C. Groß | Zendy; Walter Stummer | Zendy; Markus Missler | Zendy; Alexander Zarbock | Zendy; Dietmar Vestweber | Zendy; Heinz Wiendl | Zendy; Nicholas Schwab | Zendy

Open Access

Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis

Author(s) -

Sebastian Herich,

Tilman SchneiderHohendorf,

Astrid Rohlmann,

Maryam Khaleghi Ghadiri,

Andreas SchulteMecklenbeck,

Lisa Zondler,

Claudia Janoschka,

Patrick Ostkamp,

Jannis Richter,

Johanna Breuer,

Stoyan Dimitrov,

HansGeorg Rammensee,

Oliver Grauer,

Luisa Klotz,

Catharina C. Groß,

Walter Stummer,

Markus Missler,

Alexander Zarbock,

Dietmar Vestweber,

Heinz Wiendl,

Nicholas Schwab

Publication year - 2019

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awz301

Subject(s) - immune system , immunology , population , effector , biology , cd8 , neuroinflammation , blood–brain barrier , parenchyma , inflammation , pathology , medicine , neuroscience , central nervous system , environmental health

Specific immune-cell populations patrol the CNS in search of pathogens and tumours. Herich et al. identify CD4+ CCR5high GzmK+ effector-memory cells as a brain-surveilling subpopulation capable of crossing the uninflamed blood-brain barrier, and reveal alterations in this population in HIV+ patients with neurological symptoms and in patients with multiple sclerosis.

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