Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus | Zendy

Richard J. Burman | Zendy; Joshua S Selfe | Zendy; John Hamin Lee | Zendy; M. Berg | Zendy; A. Călin | Zendy; Neela K. Codadu | Zendy; Rebecca A. Wright | Zendy; Sarah E. Newey | Zendy; R. Ryley Parrish | Zendy; Arieh A. Katz | Zendy; Jo M. Wilmshurst | Zendy; Colin J. Akerman | Zendy; Andrew J. Trevelyan | Zendy; Joseph V. Raimondo | Zendy

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Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus

Author(s) -

Richard J. Burman,

Joshua S Selfe,

John Hamin Lee,

M. Berg,

A. Călin,

Neela K. Codadu,

Rebecca A. Wright,

Sarah E. Newey,

R. Ryley Parrish,

Arieh A. Katz,

Jo M. Wilmshurst,

Colin J. Akerman,

Andrew J. Trevelyan,

Joseph V. Raimondo

Publication year - 2019

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awz283

Subject(s) - benzodiazepine , status epilepticus , gabaa receptor , neuroscience , gabaergic , excitatory postsynaptic potential , epilepsy , medicine , psychology , pharmacology , receptor , inhibitory postsynaptic potential

Benzodiazepine-resistant status epilepticus is an ongoing clinical challenge. Burman et al. show that longer seizure duration is a useful clinical indicator of benzodiazepine resistance, and that resistance is caused by changes in GABAA receptor-mediated synaptic transmission. The findings could help optimise current management protocols.

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