Antemortem volume loss mirrors TDP-43 staging in older adults with non-frontotemporal lobar degeneration | Zendy

Alexandre Bejanin | Zendy; Melissa E. Murray | Zendy; Peter R. Martin | Zendy; Hugo Botha | Zendy; Nirubol Tosakulwong | Zendy; Christopher G. Schwarz | Zendy; Matthew L. Senjem | Zendy; Gaël Chételat | Zendy; Kejal Kantarci | Zendy; Clifford R. Jack | Zendy; Bradley F. Boeve | Zendy; David S. Knopman | Zendy; Ronald Petersen | Zendy; Caterina Giannini | Zendy; Joseph E. Parisi | Zendy; Dennis W. Dickson | Zendy; Jennifer L. Whitwell | Zendy; Keith A. Josephs | Zendy

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Antemortem volume loss mirrors TDP-43 staging in older adults with non-frontotemporal lobar degeneration

Author(s) -

Alexandre Bejanin,

Melissa E. Murray,

Peter R. Martin,

Hugo Botha,

Nirubol Tosakulwong,

Christopher G. Schwarz,

Matthew L. Senjem,

Gaël Chételat,

Kejal Kantarci,

Clifford R. Jack,

Bradley F. Boeve,

David S. Knopman,

Ronald Petersen,

Caterina Giannini,

Joseph E. Parisi,

Dennis W. Dickson,

Jennifer L. Whitwell,

Keith A. Josephs

Publication year - 2019

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awz277

Subject(s) - frontotemporal lobar degeneration , neurodegeneration , atrophy , frontotemporal dementia , degeneration (medical) , grey matter , medicine , neuroscience , psychology , pathology , magnetic resonance imaging , dementia , white matter , radiology , disease

The specific effect of TDP-43 pathology on grey matter volume in individuals without frontotemporal lobar degeneration is unclear. Bejanin et al. reveal a major and independent contribution of TDP-43 to neurodegeneration and shed light on the regional distribution of TDP-43-related atrophy in older adults.

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