Open AccessCerebral differences between dopamine-resistant and dopamine-responsive Parkinson’s tremor
Author(s) -
Michiel F. Dirkx,
Heidemarie Zach,
Annelies van Nuland,
Bastiaan R. Bloem,
Ivan Toni,
Rick C. Helmich
Publication year - 2019
Publication title -
brain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.142
H-Index - 336
eISSN - 1460-2156
pISSN - 0006-8950
DOI - 10.1093/brain/awz261
Subject(s) - dopamine , neuroscience , parkinson's disease , medicine , psychology , disease
Resting tremor in Parkinson’s disease does not always respond to dopaminergic medication. Dirkx et al. report that dopamine-resistant tremor may be the result of increased cerebellar and reduced somatosensory influences on the cerebellar thalamus, making this key node of the tremor circuit less susceptible to the inhibitory effects of dopamine.
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