Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson’s disease: an in vivo11C-BU99008 PET study | Zendy

Heather Wilson | Zendy; George Dervenoulas | Zendy; Gennaro Pagano | Zendy; Robin J. Tyacke | Zendy; Sotirios Polychronis | Zendy; Jim Myers | Zendy; Roger N. Gunn | Zendy; Eugenii A. Rabiner | Zendy; David Nutt | Zendy; Marios Politis | Zendy

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Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson’s disease: an in vivo11C-BU99008 PET study

Author(s) -

Heather Wilson,

George Dervenoulas,

Gennaro Pagano,

Robin J. Tyacke,

Sotirios Polychronis,

Jim Myers,

Roger N. Gunn,

Eugenii A. Rabiner,

David Nutt,

Marios Politis

Publication year - 2019

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awz260

Subject(s) - parkinson's disease , brainstem , medicine , neuroinflammation , basal ganglia , imidazoline receptor , pathology , neuroscience , hippocampus , temporal cortex , disease , psychology , central nervous system

Do astrocytes play a role in the initiation and progression of Parkinson’s disease? Wilson et al. reveal activation of astrocytes in early Parkinson’s disease, likely in response to the presence of abnormal proteins. Loss of astrocytes occurs upon disease progression, however, and correlates with increasing cognitive impairment.

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