Propofol-induced loss of consciousness is associated with a decrease in thalamocortical connectivity in humans | Zendy

Mahsa Malekmohammadi | Zendy; Collin M. Price | Zendy; Andrew E. Hudson | Zendy; Jasmine A T DiCesare | Zendy; Nader Pouratian | Zendy

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Propofol-induced loss of consciousness is associated with a decrease in thalamocortical connectivity in humans

Author(s) -

Mahsa Malekmohammadi,

Collin M. Price,

Andrew E. Hudson,

Jasmine A T DiCesare,

Nader Pouratian

Publication year - 2019

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awz169

Subject(s) - thalamus , propofol , local field potential , neuroscience , cortex (anatomy) , consciousness , psychology , anesthesia , medicine , functional connectivity , cerebral cortex

It is unclear how anaesthesia affects activity across brain networks. Using local field potentials recorded directly from the ventral intermediate nucleus of the thalamus and frontoparietal cortex in patients undergoing DBS surgery, Malekmohammadi et al. report the breakdown of α functional thalamocortical connectivity under propofol anaesthesia despite local power increases.

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