Deep brain stimulation has state-dependent effects on motor connectivity in Parkinson’s disease | Zendy

Joshua Kahan | Zendy; Laura Mancini | Zendy; Guillaume Flandin | Zendy; Mark White | Zendy; Anastasia Papadaki | Zendy; John S. Thornton | Zendy; Tarek Yousry | Zendy; Ludvic Zrinzo | Zendy; Marwan Hariz | Zendy; Patricia Limousin | Zendy; Karl Friston | Zendy; Thomas Foltynie | Zendy

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Deep brain stimulation has state-dependent effects on motor connectivity in Parkinson’s disease

Author(s) -

Joshua Kahan,

Laura Mancini,

Guillaume Flandin,

Mark White,

Anastasia Papadaki,

John S. Thornton,

Tarek Yousry,

Ludvic Zrinzo,

Marwan Hariz,

Patricia Limousin,

Karl Friston,

Thomas Foltynie

Publication year - 2019

Publication title -

brain

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.142

H-Index - 336

eISSN - 1460-2156

pISSN - 0006-8950

DOI - 10.1093/brain/awz164

Subject(s) - deep brain stimulation , neuroscience , stimulation , parkinson's disease , motor symptoms , disease , psychology , medicine , motor cortex , physical medicine and rehabilitation

How DBS affects information flow along basal ganglia pathways is unclear. Kahan et al. model fMRI data, revealing differences in the neuromodulatory effects of DBS during different behavioural states. The results suggest that DBS has both behaviour-independent effects on basal ganglia connectivity as well as behaviour-dependent neuromodulatory effects.

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